化合物NMS-P118 T4472

Product Introduction
Bioactivity


英文名: NMS-P118

描述: NMS-P118是可口服的高选择性PARP-1抑制剂，用于癌症治疗，在HeLa 细胞中的IC50值为0.04 μM。

体外活性: NMS-P118 proved to be a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles and high efficacy in vivo both as a single agent and in combination with Temozolomide in MDA-MB-436 and Capan-1 xenograft models, respectively. Cocrystal structures of 20by with both PARP-1 and PARP-2 catalytic domain proteins allowed rationalization of the observed selectivity.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 16 mg/mL (40.46 mM)


关键字: inhibit | NMS P118 | PARP | NMS-P-118 | NMSP118 | Inhibitor | poly ADP ribose polymerase | NMS-P 118 | NMS-P118

相关产品: Antitumor agent-104 | AG14361 | Dehydrocavidine | Iniparib | Rubiadin | Euchrestaflavanone B | Lasiodin | Olaparib | Niraparib (R-enantiomer) | ARTD10/PARP10-IN-1

相关库: Anti-Aging Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Compound Library | Inhibitor Library | Epigenetics Compound Library | Highly Selective Inhibitor Library | Anti-Cancer Active Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library

化合物NMS-P118 T4472信息由TargetMol中国为您提供，如您想了解更多关于化合物NMS-P118 T4472报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途