化合物CID 16020046 T4478

Product Introduction
Bioactivity


英文名: CID 16020046

描述: CID 16020046 (C390-0219) 是一种选择性 GPR55 拮抗剂，在酵母中抑制 GPR55 组成型活性，IC50 为 0.15 μM。它抑制 GPR55 介导的 Ca2+信号传导和 GPR55 介导的 ERK1/2 磷酸化，可降低内皮细胞的伤口愈合，参与血小板功能的调节。

体外活性: In yeast cells expressing human GPR55, CID16020046 inhibited agonist-induced receptor activation. In human embryonic kidney (HEK293) cells stably expressing human GPR55, CID16020046 behaved as an antagonist on LPI-mediated Ca2+ release and extracellular signal-regulated kinases activation, but not in HEK293 cells expressing cannabinoid receptor 1 or 2 (CB1 or CB2). CID16020046 dose-dependently inhibited lysophosphatidylinositol (LPI)-induced activation of nuclear factor of activated T-cells (NFAT), nuclear factor κ of activated B cells (NF-κB) and serum response element, translocation of NFAT and NF-κB, and GPR55 internalization [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 40 mg/mL


关键字: cells | wound | Ca2+ | inhibit | ERK1/2 | GPR55 | hERG | acetylcholinesterase | HEK | function | phosphorylation | KCNH2 | LPI | healing | endothelial | platelet | Inhibitor | HMVEC | lysophosphatidylinositol | m-opioid | G protein-coupled receptor 55 | CID16020046 | CID-16020046 | CID 16020046

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相关库: Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | GPCR Compound Library | Endocrinology-Hormone Compound Library | NO PAINS Compound Library | Anti-Alzheimer's Disease Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途