三氯卡班 T4504
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 g | 101-20-2 | ¥783.00 | 询底价 |
500 mg | 101-20-2 | ¥198.00 | 询底价 |
1 g | 101-20-2 | ¥328.00 | 询底价 |
10 g | 101-20-2 | ¥1,150.00 | 询底价 |
1 mL | 101-20-2 | ¥226.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Triclocarban
描述: Triclocarban (Cutisan) 是一种抗菌剂,用于个人清洁产品。它有潜在干扰内分泌的作用,具有调节雄激素和雌激素活性以及其他激素介导的生物过程的能力。
体外活性: Triclocarban (300 nM) potentiates the cytotoxicity of 300 μM H2O2 in rat thymocytes. Triclocarban (300 nM) itself does not increase the population of dead cells, it facilitates the process of cell death induced by H2O2, resulting in further increase in the population of dead cells [1]. Triclocarban exerts estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells [2].
体内活性: Triclocarban is absorbed significantly from soap used during showering in human subjects and that its Cmax in their whole blood ranges from 23 nM to 530 nM[1]. Gestational triclocarban exposure does not affect the ability of dams to carry offspring to term but triclocarban exposure during lactation has adverse consequences on the survival of offspring[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45 mg/mL (142.59 mM)
关键字: Bacterial | endocrine-disrupting | inhibit | Triclocarban | personal | products | cleaning | Inhibitor | antimicrobial
相关产品: Ionomycin calcium | Qstatin | Oridonin | Chlorphenesin | Diniconazole | Lawsone methyl ether | Polyphyllin VI | AX20017 | Sanguinarine chloride | Piperacillin sodium
相关库: Drug Repurposing Compound Library | Approved Drug Library | Antibiotics Library | ReFRAME Related Library | FDA-Approved & Pharmacopeia Drug Library | Drug-induced Liver Injury (DILI) Compound Library | Bioactive Compounds Library Max | Anti-Bacterial Compound Library | NO PAINS Compound Library | Anti-Infection Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途