盐酸哌罗克生 T4526

Product Introduction
Bioactivity


英文名: Piperoxan hydrochloride

描述: Piperoxan hydrochloride (Benodaine hydrochloride) 是第一代抗组胺剂，是一种 α2肾上腺素受体拮抗剂。

体外活性: When the medulla is superfused with Piperoxan (50 μM; 5 min) while the pons is with artificial cerebrospinal fluid (ACSF), the three inactive preparations display rhythmic phrenic bursts at a low frequency (2-4 c/min), and the phrenic burst frequency of the 12 active ones significantly increases during the last 3 min of Piperoxan applications (163±12% of the previous mean frequency). In active medullary preparations, the effects of NA applications (25 μM; 5 min) are compared when the preparations are superfused either by ACSF (n=8) or by the α2 adrenoceptor antagonist Piperoxan (50 μM; PIP-ACSF; n=5). NA applications either alone (NA-ACSF) or with Piperoxan (PIP-ACSF+NA) significantly increases the phrenic burst frequency. However, the blockage of the medullary α2 adrenoceptors by Piperoxan potentiates a phrenic burst frequency increase: during the fifth minute of NA applications, the phrenic burst frequency reached 171±11% of the mean control value when ACSF is applied alone and 234±21% of the mean control value when PIP-ACSF is applied in control condition[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (185.34 mM)


关键字: Piperoxan hydrochloride | Piperoxan | Beta Receptor | Adrenergic Receptor | inhibit | Inhibitor | Piperoxan Hydrochloride | Benodaine Hydrochloride | dl-Piperoxan Hydrochloride | Benodaine

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相关库: Anti-Neurodegenerative Disease Compound Library | Anti-Hypertension Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | GPCR Compound Library | Endocrinology-Hormone Compound Library | NO PAINS Compound Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途