异卡波肼 T4559

Product Introduction
Bioactivity


英文名: Isocarboxazid

描述: Isocarboxazid 是不可逆的、非选择性的单胺氧化酶 monoamine oxidase 抑制剂，其在大鼠大脑中测得的 IC50值为4.8 μM。

体外活性: In vivo studies demonstrated isocarboxazid-driven inhibition of MAO in the brain, heart, and liver. The reduced MAO activity, caused by isocarboxazid, results in an increased concentration of serotonin, epinephrine, norepinephrine, and dopamine in storage sites throughout the central nervous system (CNS) and sympathetic nervous system. The increase of one or more monoamines is the basis for the antidepressant activity of MAO inhibitors like isocarboxazid.[1]

体内活性: In vitro studies demonstrated isocarboxazid-driven inhibition of MAO in the brain, heart, and liver. The reduced MAO activity, caused by isocarboxazid, results in an increased concentration of serotonin, epinephrine, norepinephrine, and dopamine in storage sites throughout the central nervous system (CNS) and sympathetic nervous system. The increase of one or more monoamines is the basis for the antidepressant activity of MAO inhibitors like isocarboxazid.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (216.22 mM)


关键字: Isocarboxazid | inhibit | Monoamine Oxidase | MAO | Inhibitor

相关产品: Bifemelane hydrochloride | Phenelzine sulfate | Toloxatone | Lysyl hydroxylase 2-IN-1 | hMAO-B-IN-5 | PXS-5120A | MAO A/HSP90-IN-2 | IHC3 | PXS-4728A | PAT-1251

相关库: Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Approved Drug Library | ReFRAME Related Library | Mitochondria-Targeted Compound Library | Drug-induced Liver Injury (DILI) Compound Library | Inhibitor Library | Reprogramming Compound Library | NO PAINS Compound Library | Covalent Inhibitor Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途