化合物ML-098 T4619

Product Introduction
Bioactivity


英文名: ML-098

描述: ML-098 (CID-7345532) 是 GTP 结合蛋白 Rab7的一种激活剂，EC50值为77.6nM。

体外活性: ML098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II. ML-098 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM which shows selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively)[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (161.6 mM)


关键字: ML-098 | inhibit | ML 098 | Inhibitor | CID 7345532 | Ras | CID7345532 | ML098

相关产品: KRAS G12C inhibitor 17 | MC 976 | ML-210 | CCG-203971 | BI-2852 | PROTAC K-Ras Degrader-1 | Digeranyl bisphosphonate | Atranorin | RMC-4998 | KRAS inhibitor-9

相关库: Anti-Cancer Metabolism Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Anti-Ovarian Cancer Compound Library | GPCR Compound Library | Kinase Inhibitor Library | Anti-Colorectal Cancer Compound Library | Apoptosis Compound Library | Reprogramming Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途