西拉美新 T4620

Product Introduction
Bioactivity


英文名: Siramesine

描述: Siramesine (Lu 28-179) 是sigma-2受体激动剂，通过线粒体的不稳定溶酶体触发细胞死亡，有强大的抗癌活性。它对 sigma-2 受体具有亚纳摩尔亲和力，IC50为 0.12 nM。它对 sigma-2 受体的选择性是 sigma-1 受体的 140倍，IC50为 17 nM。

体内活性: SA4503 or siramesine given jointly with MEM (as well as with AMA) decreased the immobility time in rats. The effect of SA4503 and AMA co-administration was antagonized by progesterone, a sigma1 receptor antagonistic neurosteroid.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Inhibitor | lysosomes | inhibit | death | cathepsin | Sigma Receptor | mitochondria | selectivity | cancer | Siramesine

相关产品: S1R agonist 1 hydrochloride | BD1063 dhydrochloride | BMY-14802 | NE-100 hydrochloride | 4-PPBP maleate | Cutamesine dihydrochloride | AD186 | Blonanserin | Dimemorfan phosphate | Glycerol phenylbutyrate

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途