化合物Fer and FerT inhibitor T4638
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 1241537-79-0 | ¥2,560.00 | 询底价 |
50 mg | 1241537-79-0 | ¥8,450.00 | 询底价 |
1 mg | 1241537-79-0 | ¥997.00 | 询底价 |
100 mg | 1241537-79-0 | ¥11,300.00 | 询底价 |
10 mg | 1241537-79-0 | ¥3,790.00 | 询底价 |
25 mg | 1241537-79-0 | ¥6,130.00 | 询底价 |
Product Introduction
Bioactivity
英文名: E260
描述: E260 (Fer and FerT inhibitor) 是Fer/FerT 激酶抑制剂。
体外活性: Fer and FerT inhibitor, which selectively evokes metabolic stress in cancer cells by imposing mitochondrial dysfunction and deformation, and onset of energy-consuming autophagy which decreases the cellular ATP level. When applied to metastatic grade IV SW620 CC cells, which are serum starved for 16 h and treated with 3 mM H2O2 to activate Fer,Fer and FerT inhibitor exhibits inhibitory effects on the Fer-kinase activity as is reflected by suppressed auto-phosphorylation activity of the enzyme.
体内活性: Fer/FerT kinase inhibitor suppresses xenografts progression in vivo. The pharmacokinetic (PK) profile of Fer/FerT kinase inhibitor is determined in mice. Fer/FerT kinase inhibitor exhibits a T1/2?of 175 min in the blood, and a volume of distribution of 4244 mL/kg suggesting an efficient distribution of the compound in the animal tissues. To evaluate the efficacy of Fer/FerT kinase inhibitor on tumor growth, SW620 cells are subcutaneously introduced into immuno-compromised "Nude" mice. Administration of Fer/FerT kinase inhibitor leads to a significant attenuation of tumor progression throughout the experiment, and to a 10-fold decrease in average tumor volume after 22 days of treatment. To further demonstrate the anti-cancer activity of Fer/FerT kinase inhibitor in vivo, mice bearing SW48 cells derived xenografts are treated with Fer/FerT kinase inhibitor and the tumor progression profiles are determined. Mice treated with Fer/FerT kinase inhibitor demonstrate a 5-6-fold attenuation in tumors progression when compared to the control treated group
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : Slightly soluble
关键字: E 260 | Inhibitor | E260 | inhibit | E-260
相关库: Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library
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