化合物 T4667 T4667

Product Introduction
Bioactivity


英文名: EOS-62062

描述: Pesampator (PF-04958242) 是有效的、高度选择性的 AMPA 受体的正变构调节剂 (AMPA 增强剂)，EC50为 310 nM，Ki 为 170 nM。

体内活性: Pesampator (0.1-1 mg/kg; SC) dose-dependently increases CD-1 mouse cerebellum cGMP and Pesampator (0.1-0.32 mg/kg; SC) decreases fall latency in C57BL/6J mice traversing an accelerating rotarod [1]. Pesampator (0.001-0.01 mg/kg; male Sprague-Dawley rats) reverses the MK-801-mediated (0.05 mg/kg; IV) reduction in paired-pulse facilitation (PPF) after cumulative or a single (0.01 mg/kg) intravenous dose [1]. Pesampator (0.0032–0.032 mg/kg; SC) reduces ketamine-induced working memory disruptions in rats as determined by mean errors in a radial arm maze [1]. Pesampator (0.027, 0.08, and 0.60 mg/kg; SC) dose-dependently affectes the regional brain uptake of 2-deoxy-2-[ 18F ]fluoro-d-glucose (FDG) in rats [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: EOS 62062 | EOS62062 | EOS-62062

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途