盐酸药根碱 T4912

Product Introduction
Bioactivity


英文名: Jatrorrhizine chloride

描述: Jatrorrhizine chloride (Neprotine chloride) 是从黄连中分离得到的生物碱，具有神经保护、抗菌、抗氧化和抗疟原虫活性。它通过抑制摄取2转运蛋白的活性减少血清素和去甲肾上腺素的摄取。它是具有口服活性的乙酰胆碱酯酶抑制剂。

体外活性: Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters. Jatrorrhizine chloride significantly inhibits the PMAT-mediated MPP+ uptake in a concentration-dependent manner (IC50: 1.05 μM). Jatrorrhizine chloride demonstrates a more powerful inhibition on 5-HT and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 5 mg/mL (13.38 mM)


关键字: Jatrorrhizine | Bacterial | antiamoebic | depressive disorder | neuroprotective | Jatrorrhizine chloride | Jatrorrhizine Chloride | antimicrobial | Cytotoxic | 5-HT Receptor | alkaloid | Serotonin Receptor | antioxidant | Inhibitor | inhibit | Yatrorhizine Chloride | Neprotine Chloride | antiplasmodial | antidepressant | quaternary isoquinoline | antidepressant-like | Alzheimer’s disease | Cholinesterase (ChE) | 5-hydroxytryptamine Receptor | E. histolytica | falciparum

相关产品: PNU-142633 | Eplivanserin | Bemesetron | Intepirdine | Escin IB | MK 212 hydrochloride | Arotinolol | Volinanserin | Donitriptan hydrochloride | AVN-492

相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | Inhibitor Library | GPCR Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Parasitic Compound Library | Natural Product Library for HTS

盐酸药根碱 T4912信息由TargetMol中国为您提供，如您想了解更多关于盐酸药根碱 T4912报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途