头孢唑兰盐酸盐 T4984

Product Introduction
Bioactivity


英文名: Cefozopran hydrochloride

描述: Cefozopran hydrochloride (SCE-2787 hydrochloride) 是一种半合成的非肠道头孢菌素。它是一种广谱抗菌抗生素，能抑制大多数革兰氏阴性和革兰氏阳性菌。

体外活性: Cefozopran hydrochloride (SCE-2787 hydrochloride), a fourth-generation cephalosporin, exhibits substantial activity against a range of bacteria. Cefozopran hydrochloride is effective against gram-positive organisms, including methicillin-susceptible staphylococci, enterococci, and viridans group streptococci. Additionally, Cefozopran hydrochloride demonstrates efficacy against gram-negative organisms such as Hemophilus influenza. Notably, Cefozopran hydrochloride displays comparatively good activity against enterococci and P. aeruginosa, which are typically resistant to other cephalosporins[2].

体内活性: In four-week-old ICR male mice, Cefozopran hydrochloride, administered subcutaneously at doses ranging from 5 to 80 mg/kg twice a day for 5 days, proves effective against acute respiratory tract infections caused by Kiebsiella pneumonia DT-S. In a model of chronic respiratory tract infection induced by K. pneumoniae 27, Cefozopran hydrochloride, at doses between 20 and 80 mg/kg administered subcutaneously twice a day for 7 days in five-week-old CBA/J female mice, exhibits effectiveness comparable to Ceftazidime[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 30 mg/mL (54.35 mM)
DMSO : 30 mg/mL (54.35 mM)


关键字: Cefozopran Hydrochloride | SCE2787 Hydrochloride | SCE-2787 Hydrochloride | SCE 2787 Hydrochloride

相关产品: Difenoconazole | beta-Amyrin acetate | Tetrazolast | Sodium Houttuyfonate | Climbazole | Benodanil | antifungal-agent-6 | Triticonazole | Dichlorophen | Hexetidine

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途