高车前苷 T4S0217

Product Introduction
Bioactivity


英文名: HOMOPLANTAGININ

描述: Homoplantaginin 是来自中药荔枝草的一种类黄酮，具有抗炎和抗氧化活性。

体外活性: Homoplantaginin可用于预防和治疗与胰岛素抵抗有关的内皮功能障碍，它通过抑制炎症和调节细胞信号传导（通过IKKβ/IRS-1/pAkt/peNOS途径）来改善内皮细胞的胰岛素抵抗。

体内活性: Homoplantaginin displayed an antioxidant property in a cell-free system and showed IC(50) of reduction level of DPPH radical at 0.35 microg/ml. In human hepatocyte HL-7702 cells exposed to H(2)O(2), the addition of 0.1-100 microg/ml of Homoplantaginin, which did not have a toxic effect on cell viability, significantly reduced lactate dehydrogenase (LDH) leakage, and increased glutathione (GSH), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in supernatant. In vivo assay, we employed the model of Bacillus Calmette-Guérin (BCG)/lipopolysaccharide (LPS)-induced hepatic injury mice to evaluate efficacy of Homoplantaginin. Homoplantaginin (25-100mg/kg) significantly reduced the increase in serum alanine aminotranseferase (ALT) and aspartate aminotransferase (AST), decreased the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1). The same treatment also reduced the content of thiobarbituric acid-reactive substances (TBARS), elevated the levels of GSH, GSH-Px and SOD in hepatic homogenate. The histopathological analysis showed that the grade of liver injury was ameliorated with reduction of inflammatory cells and necrosis of liver cells in Homoplantaginin treatment mice.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (216.26 mM)


关键字: inhibit | Inhibitor | TNFR | HOMOPLANTAGININ | TNF Receptor | Nuclear factor-κB | Tumor Necrosis Factor Receptor | NF-κB | Nuclear factor-kappaB

相关产品: Anatabine | 25R-Inokosterone | Nodinitib-1 | Pinostrobin | Incensole acetate | Manassantin B | Isorhamnetin 3-O-galactoside | Utomilumab | Desoxo-narchinol A | Belantamab

相关库: Antioxidant Compound Library | Anti-Breast Cancer Compound Library | Immuno-Oncology Compound Library | Bioactive Compounds Library Max | Antidepressant Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Tibetan medicine Compound Library | Bioactive Compound Library

高车前苷 T4S0217信息由TargetMol中国为您提供，如您想了解更多关于高车前苷 T4S0217报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途