石榴皮鞣素 T4S1718

Product Introduction
Bioactivity


英文名: Punicalin

描述: Punicalin 是从Punica granatumL. 或Terminalia catappaL. 的叶子中分离的，一种可水解的单宁，具有抗炎活性。它是一种抗乙型肝炎病毒药物。

动物实验: Edema in the left hind paw of rats was induced by injecting 0.05 ml of 1% (w/v) carrageenan into the limb.?Animals were divided into six groups with eight animals in each group.?The drug test groups were treated with 5 or 10 mg/kg body weight of each component 1 hr before carrageenan injection.?The animals in the control group received saline.?Another group of rats was administered 5 mg/kg indomethacin as a standard anti-inflammatory drug.

体外活性: The edema after carrageenan injection is believed to be biphasic in nature.?The initial phase, beginning 1 hr after carrageenan administration, is due to the release of histamine and serotonin.?The second phase occurs 2 to 5 hr after carrageenan administration.??is induced by the release of bradykinin, protease, prostaglandin and lysosome ?.?It has been reported that the second phase of edema is sensitive to most clinically effective anti-inflammatory agents, such as indomethacin.?However, that treatment with punicalagin and punicalin is effective against both phases of inflammation induced by carrageenan.

体内活性: Punicalagin and punicalin were the active components of T. catappa L., a hepatoprotective crude drug used in Southern Asia, and both found to exhibit great antioxidant activity and hepatoprotective effect on CC14- or acetaminophen-induced liver damages. Even if they had great antioxidant effects in smaller concentration in vitro, treatment with larger doses of punicalagin and punicalin yield liver cell damage in rats.?In studying their anti-inflammatory effects, similar results were also observed.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (31.95 mM)


关键字: hepatitis | inhibit | Punicalin | virus | Hepatitis B virus | Inhibitor | Tannin | HBV | anti-inflammatory

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相关库: Anti-Aging Compound Library | Terpene Natural Product Library | Bioactive Compounds Library Max | Chinese Pharmacopoeia Natural Product Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Anti-Viral Compound Library | Natural Product Library | Anti-infective Natural Product Library

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