替普瑞酮 T5008

Product Introduction
Bioactivity


英文名: Teprenone

描述: Teprenone (Geranylgeranylacetone) 是一种热休克蛋白诱导剂，有抗溃疡作用。

体外活性: Teprenone is an HSPs inducer. Teprenone (Geranylgeranylacetone, 1 μM) significantly prevents ethanol-induced exfoliation and reduces lactate dehydrogenase (LDH) release in gastric mucosal cells. Teprenone (1 μM) gradually increases HSC70 level, and rapidly accumulates the stress-inducible HSP90, HSP70, and HSP60 concentrations within 30-60 min. Teprenone also activates the heat shock factor 1. Teprenone (0-20 µM) slightly increases human umbilical vein endothelial cell (HUVEC) viability following irradiation (IR). Teprenone (10 µM) exhibits no effects on HUVEC migration and invasion, but enhances HUVEC tube formation and wound healing both with and without IR. Teprenone (10 µM) also promotes angiogenesis via inducing VEGF and eNOS expression in HUVECs.

体内活性: Teprenone (200 mg/kg, p.o.) results in the accumulation of HSP70 mRNA in rats, and the accumulation is enhanced by stress addition in the mucosa of Teprenone-pretreated rats than that of vehicle-pretreated rats. Teprenone (200 mg/kg, p.o.) markedly suppresses the ulcer formation after 2- and 4-hour stress loading in rats[1]. Teprenone (200 mg/kg daily) induces HSP72 in retinal ganglion cells (RGCs) from rat retinas. Teprenone significantly reduces the loss of RGCs (evaluated after intraocular pressure (IOP) elevation), lessens optic nerve damage, decreases the number of TUNEL-positive cells in the RGC layer, and increases HSP72 in a rat model of glaucoma[2]. Teprenone (200 mg/kg, p.o.) shows protective effect on radiation-induced intestinal injury in mice.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (75.63 mM)


关键字: Inhibitor | HSP | Teprenone | Heat shock proteins | inhibit

相关产品: Luminespib | Radicicol | HSP90-IN-19 | HSP70/SIRT2-IN-2 | Grp94 Inhibitor-1 | HA15 | Debio 0932 | Geldanamycin | JG-231 | BX-2819

相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | Approved Drug Library | Anti-Cancer Drug Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Approved Drug Library | Metabolism Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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