乳清酸一水合物 T5078
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 g | 50887-69-9 | ¥163.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Orotic acid monohydrate
描述: Orotic acid monohydrate (2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate) 是内源性代谢产物的一种。
体外活性: Orotic acid increases cell proliferation and decreases apoptosis in serum-starved SK-Hep1 hepatocellular carcinoma cells, which may ascribe to the inhibition of AMP-activated protein kinase (AMPK) phosphorylation and thus activation of mammalian target of rapamycin complex 1 (mTORC1) [1].
体内活性: Male Fischer 344 rats (130-150 g) to two-thirds PH in the absence or in the presence of Orotic acid (a 300-mg tablet of Orotic acid methyl ester implanted intraperitoneally at the time of two-thirds PH). treatment with Orotic acid resulted in a near-100% inhibition of RNR induced by two-thirds PH in rat liver, as monitored by enzyme activity and protein level [2]. Feeding 1% Orotic acid with diet decreased the phosphorylation of AMPK and increased the maturation of SREBP-1 and the expression of SREBP-responsive genes in the rat liver. Orotic acid-induced lipid accumulation was also completely inhibited by rapamycin. Mouse hepatocytes and mice were resistant to Orotic acid-induced lipogenesis because of little if any response in AMPK and downstream effectors [3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 2.5 mg/mL (14.36 mM)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 1 mg/mL (insoluble or slightly soluble)
关键字: Orotic acid | Endogenous Metabolite | Inhibitor | Orotic acid Monohydrate | 2,4-dioxo-1H-pyrimidine-6-carboxylic acid Hydrate | inhibit
相关产品: 2'-Deoxyuridine | Oleamide | Thymidine-5'-monophosphate disodium salt | 2'-Deoxyuridine 5'-monophosphate disodium | Thymopentin | trans-Cyclohexane-1,2-diol | Sucrose | Dodecanoylcarnitine | Stearoylcarnitine | Itaconic acid
相关库: Nucleotide Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | NO PAINS Compound Library | Natural Product Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途