化合物DJ-V159 T5100
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 2253744-53-3 | ¥159.00 | 询底价 |
500 mg | 2253744-53-3 | ¥6,910.00 | 询底价 |
25 mg | 2253744-53-3 | ¥1,150.00 | 询底价 |
10 mg | 2253744-53-3 | ¥567.00 | 询底价 |
5 mg | 2253744-53-3 | ¥347.00 | 询底价 |
50 mg | 2253744-53-3 | ¥1,960.00 | 询底价 |
2 mg | 2253744-53-3 | ¥219.00 | 询底价 |
100 mg | 2253744-53-3 | ¥3,190.00 | 询底价 |
1 mL | 2253744-53-3 | ¥383.00 | 询底价 |
Product Introduction
Bioactivity
英文名: DJ-V-159
描述: DJ-V-159 (DJ-V159) 是一种G 蛋白偶联受体家族C 组6 A 的激动剂。
体外活性: DJ-V159 activates ERK in HEK-293 transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. In addition, DJ-V159 dose-dependently stimulates cAMP production in GPRC6A expressing HEK-293 cells, achieving a response a 0.2 nM concentrations in the media. DJ-V159 stimulates insulin secretion in mouse beta-cell MIN-6 cells. The DJ-V159 increased insulin stimulation index (SI) in MIN-6 cells similar to the effects of Ocn, known ligand of GPRC6A [1].
体内活性: DJ-V-159 (10 mg/kg, i.p.) reduces blood glucose levels in wild-type mice at 60 and 90 minutes, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 (10 mg/kg, i.p.) reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 5.02 mg/mL (10 mM)
关键字: DJV159 | DJ-V-159 | Inhibitor | Androgen Receptor | inhibit | DJ V 159 | DJ-V 159
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相关库: Anti-Prostate Cancer Compound Library | Transcription Factor-Targeted Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Nuclear Receptor Compound Library | Endocrinology-Hormone Compound Library | NO PAINS Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途