化合物SRI-011381 hydrochloride T5129

Product Introduction
Bioactivity


英文名: SRI-011381 hydrochloride

描述: SRI-011381 hydrochloride 是口服具有活力的TGF-β信号通路的激活剂，具有神经保护活性。

体外活性: SRI-11381 is neuroprotective. SRI-011381 promote fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages.

体内活性: SRI-011381 protects mice against kainic acid-induced excitotoxicity and neurodegeneration. SRI-011381 (30 mg/kg, dissolved in DMSO) is injected (i.p.) into the SBE-luc mice. SRI-011381 is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%. SRI-011381 by oral gavage of 10, 30, and 75 mg/kg for 14 days resulted in significant changes in hematological endpoints, most notably reductions in red blood cells, hematocrit and hemoglobin. SRI-011381 reduces neurodegeneratio in APP751Lon, Swetransgenic mice.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 12 mg/mL (32.79 mM)
H2O : 76.92 mg/mL (210 mM)


关键字: SRI 011381 hydrochloride | multiple | Transforming growth factor beta | sclerosis | TGF-beta/Smad | α-SMA | NALP3 | SRI 011381 | collagen-1 | SRI-011381 | inhibit | TGF-β | SRI011381 Hydrochloride | neuroprotective | SRI-011381 Hydrochloride | SRI011381 | Inhibitor | SRI011381 hydrochloride | SRI 011381 Hydrochloride

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相关库: Anti-Neurodegenerative Disease Compound Library | Anti-Breast Cancer Compound Library | Bioactive Compounds Library Max | CNS-Penetrant Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Fibrosis Compound Library | TGF-beta/Smad Compound Library | Stem Cell Differentiation Compound Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compound Library

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