化合物BCI-121 T5322
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 432529-82-3 | ¥559.00 | 询底价 |
25 mg | 432529-82-3 | ¥1,980.00 | 询底价 |
100 mg | 432529-82-3 | ¥4,380.00 | 询底价 |
50 mg | 432529-82-3 | ¥2,970.00 | 询底价 |
10 mg | 432529-82-3 | ¥898.00 | 询底价 |
1 mL | 432529-82-3 | ¥559.00 | 询底价 |
1 mg | 432529-82-3 | ¥247.00 | 询底价 |
Product Introduction
Bioactivity
英文名: BCI-121
描述: BCI-121是一种底物竞争性 SMYD3 抑制剂,可抑制癌细胞的增殖。
细胞实验: Cell proliferation is determined using the cell proliferation reagent WST-1. Cells are seeded into 96-well plates one day before treatment. After 48 h, 72 h, or 96 h of BCI-121 or DMSO exposure, 10 μL of the Cell Proliferation Reagent WST-1 are added to each well and incubated at 37 °C in a humidified incubator for up to 1 h. Absorbance is measured on a microplate reader at 450/655 nm. The proliferation index is calculated as the ratio of WST-1 absorbance of treated cells to WST-1 absorbance of control cells.
体外活性: BCI-121 significantly reduced the proliferation of HT29 (by 46%) and HCT116 (by 54%) cells at 72 h and decreased the expression levels of SMYD3 target genes. BCI-121 treatment only affected proliferation of cancer cell lines expressing high levels of SMYD3. The high levels of SMYD3 expression detected in OVCAR-3 cells, along with the strong reduction in proliferation rate observed upon BCI-121 treatment.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 100 mg/mL (293.93 mM)
关键字: inhibit | BCI121 | Histone Methyltransferase | Inhibitor | BCI-121 | BCI 121
相关产品: BAY-6035 | SETDB1-TTD-IN-1 | UNC6934 | UNC0642 | Gambogenic acid | Antitumor agent-101 | EPZ005687 | SGC0946 | MRK-740 | Amodiaquine dihydrochloride dihydrate
相关库: Anti-Aging Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Anti-Cancer Active Compound Library | Stem Cell Differentiation Compound Library | Reprogramming Compound Library | Histone Modification Compound Library | Bioactive Compound Library
化合物BCI-121 T5322信息由TargetMol中国为您提供,如您想了解更多关于化合物BCI-121 T5322报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途