化合物KKL-35 T5331
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
2 mg | 865285-29-6 | ¥636.00 | 询底价 |
50 mg | 865285-29-6 | ¥5,390.00 | 询底价 |
5 mg | 865285-29-6 | ¥1,050.00 | 询底价 |
1 mg | 865285-29-6 | ¥437.00 | 询底价 |
1 mL | 865285-29-6 | ¥1,380.00 | 询底价 |
10 mg | 865285-29-6 | ¥1,730.00 | 询底价 |
100 mg | 865285-29-6 | ¥7,890.00 | 询底价 |
25 mg | 865285-29-6 | ¥3,490.00 | 询底价 |
Product Introduction
Bioactivity
英文名: KKL-35
描述: KKL-35 是一种具有广谱抗生素活性的反式翻译抑制剂,IC50值为 0.9 µM。
细胞实验: Overnight cultures of S. flexneri 2a 2457T, B. anthracis, M. smegmatis, JW5503, and NSR253 were grown in lysogeny broth (LB). Cultures were diluted to a final inoculum of ~5 × 10^5 cfu/mL in 96-well microtiter plates, compounds were added at appropriate concentrations, and growth was observed after 24-h incubation at 37 °C. The MIC was determined by the concentration of the compound in the last well that showed no bacterial growth. For MBC assays, 10 μL from wells containing the MIC, 2× MIC, and 4× MIC of each compound was diluted 10-fold, spotted on LB plates, and grown overnight at 37 °C. An inhibitor was scored as bactericidal if it resulted in 1,000-fold reduction in colony-forming units per milliliter from the original inoculum [1].
体外活性: KKL-35 inhibited tagging of DHFR-ns. Dose-response experiments showed that KKL-35 inhibited tagging with an IC50 = 0.9 μM. KKL-35 prevented the growth of WT S. flexneri with a minimum inhibitory concentration (MIC) of 6 μM, and the addition of KKL-35 to a growing culture of S. flexneri stops growth [1]. Consistent with the essential nature of trans-translation in L. pneumophila, KKL-35 inhibited the growth of all tested strains at submicromolar concentrations. KKL-35 remained equally active against L. pneumophila mutants that have evolved resistance to macrolides. KKL-35 inhibited the multiplication of L. pneumophila in human macrophages at several stages of infection [2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 8.33 mg/mL (26.23 mM)
关键字: Bacterial | Inhibitor | KKL-35 | KKL 35 | inhibit | KKL35
相关产品: trans-Cinnamic acid | Chitosan (MW 150000) | Meptyldinocap | D-Cycloserine | Cefditoren pivoxil | Piperlongumine | Cinnamylideneacetic acid | Cetalkonium chloride | Sudan I | Cecropin A
相关库: Antibiotics Library | Drug-induced Liver Injury (DILI) Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Bacterial Compound Library | NO PAINS Compound Library | Bioactive Compound Library | Anti-Infection Compound Library
化合物KKL-35 T5331信息由TargetMol中国为您提供,如您想了解更多关于化合物KKL-35 T5331报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途