化合物S63845 T5346

Product Introduction
Bioactivity


英文名: S63845

描述: S63845 是一种选择性骨髓细胞白血病 1 抑制剂，结合人 MCL1的 Kd 值为 0.19 nM。

体外活性: S63845, a small molecule that specifically binds with high affinity to the BH3-binding groove of MCL1.?S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway[1].

体内活性: In vivo, S63845 shows potent anti-tumour activity with an acceptable safety margin as a single agent in several cancers.?Moreover, MCL1 inhibition, either alone or in combination with other anti-cancer drugs, proved effective against several solid cancer-derived cell lines.?MCL1 as a target for the treatment of a wide range of tumours[1].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 33.33 mg/mL (40.19 mM)


关键字: S 63845 | Inhibitor | S63845 | S-63845 | Bcl-2 Family | inhibit

相关产品: Pyridoclax | Bcl-xL antagonist 2 | Metaproterenol | 6-Acetonyldihydrochelerythrine | Paris saponin VII | 2',3'-Dehydrosalannol | Bz 423 | Venetoclax | Bcl-B inhibitor 1 | Kurarinone

相关库: Anti-Cancer Compound Library | Inhibitor Library | Hematonosis Compound Library | Apoptosis Compound Library | Cuproptosis Compound Library | NO PAINS Compound Library

化合物S63845 T5346信息由TargetMol中国为您提供，如您想了解更多关于化合物S63845 T5346报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途