二十二碳六烯酸 T5369

Product Introduction
Bioactivity


英文名: Docosahexaenoic Acid

描述: Docosahexaenoic Acid 是一种ω-3脂肪酸，在脑和视网膜中较为丰富，且能够直接从鱼油和母乳中获得。

体外活性: When monocytes were differentiated to dendritic cells (DCs) in the presence of docosahexaenoic acid (DHA), the expression of costimulatory and antigen presentation markers was altered in a concentration-dependent way, positively or negatively, depending on the markers tested and the maturation stage of the DCs. DHA-treated, mature DCs showed inhibition of IL-6 expression and IL-10 and IL-12 secretion, and their lymphoproliferative stimulation capacity was impaired [1].

体内活性: An experimental model of PD was created by four intraperitoneal injections of MPTP (4 × 20 mg/kg, at 12h intervals). Docosahexaenoic acid was given daily by gavage for 4 weeks (36 mg/kg/day). The number of apoptotic dopaminergic cells significantly increased in MPTP-treated mice compared to controls. Although DHA significantly diminished the number of cell deaths in MPTP-treated mice, it did not improve the decreased motor activity observed in the experimental PD model. Docosahexaenoic acid significantly diminished the amount of cell death in the MPTP+DHA group as compared to the MPTP group [2].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (304.42 mM)
H2O : 5 mg/mL (15.22 mM)


关键字: inhibit | Docosahexaenoic Acid | Inhibitor | Endogenous Metabolite

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