盐酸苄普地尔 T5391

Product Introduction
Bioactivity


英文名: Bepridil hydrochloride

描述: Bepridil hydrochloride (CERM 1978) 是一种钙通道阻滞剂，还抑制 Na+/Ca2+ 交换(NCX)、钠通道和心脏肌膜 KATP 通道，具有抗心绞痛的作用。

体外活性: Bepridil (1-100 microM) inhibited the K(ATP) channel current in a concentration-dependent manner. The IC(50) value of bepridil was estimated to be 10.5 microM for outward K(ATP) channel currents (holding potential, +60 mV) and 6.6 microM for inward K(ATP) channel currents (holding potential, -60 mV). Bepridil (0.1-30 microM) also inhibited K(Na) channel currents measured at the holding potential of -60 mV, in a concentration-dependent manner with an IC(50) value of 2.2 microM [2].

体内活性: The predominant effects of Bepridil (cumulative dose = 9.0 mg/kg i.v.) in the conscious rat were reduced coronary vascular resistance and heart rate. Bepridil showed selectivity for the coronary circulation since systemic vascular resistance was not significantly reduced until cumulative i.v. dosage of 21.0 mg/kg was administered [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 130 mg/mL (322.58 mM)


关键字: CERM1978 | Calcium Channel | inhibit | Ca2+ channels | Bepridil | Bepridil hydrochloride | CERM-1978 | Inhibitor | Ca channels | Bepridil Hydrochloride

相关产品: Ionomycin calcium | Saikogenin D | MRS1845 | Myoregulin | AE0047 Hydrochloride | Dehydronitrosonisoldipine | Tamolarizine | Amlodipine Besylate | Nicardipine | Praeruptorin C

相关库: Ion Channel Inhibitor Library | Drug Repurposing Compound Library | Anti-Hypertension Compound Library | ReFRAME Related Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Metabolism Compound Library | NO PAINS Compound Library

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