化合物SNAP-94847 T5406
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 487051-12-7 | ¥6,670.00 | 询底价 |
1 mL | 487051-12-7 | ¥1,870.00 | 询底价 |
25 mg | 487051-12-7 | ¥5,130.00 | 询底价 |
Product Introduction
Bioactivity
英文名: SNAP 94847
描述: SNAP 94847 (SNAP-94847) 是一种选择性黑色素浓缩激素受体1 拮抗剂,Ki 为 2.2 nM。它具有抗焦虑和抗抑郁活性,可减少小鼠的食物摄入。
动物实验: Chronically treated Sprague–Dawley rats were administered fluoxetine (18 mg/kg/day) or SNAP 94847 (20 mg/kg/day) via oral gavage in 20% beta-cyclodextrin for 2 weeks (1 injection, 6 h into light cycle). For acute treatment, drugs were given orally in 20% betacyclodextrin 1 h before testing. On each test day, locomotor activity was recorded during a 60 min habituation to the novel locomotor cage, after which the rats were administered quinpirole (0.3 mg/kg, i.p.) and returned immediately to the cage, where locomotor activity was measured for an additional 180 min. In each case-control animals were administered the corresponding vehicle, without drug [2].
体外活性: SNAP-94847 showed a favorable combination of MCH1 receptor affinity (Ki: 2.2 nM) and human R1A receptor (>80-fold) and D2 (>500-fold) selectivity [1].
体内活性: SNAP-94847 (10 mg/kg, p.o.) had no effect on basal water consumption measured over 2 h: vehicle-treated (2.0 mL); 16g-treated (2.3 mL). MCH-evoked water intake was inhibited significantly by SNAP-94847 at doses of 1.0, 2.5, and 10 mg/kg [1]. BALB/c mice treated for 21 days with fluoxetine or SNAP 94847 (20 mg/kg/day) showed marked increases in quinpirole-induced locomotor activity, with the onset of hyper-locomotion appearing earlier in the time course after SNAP 94847 compared to fluoxetine. Administration of either compound for 7 days was also sufficient to augment the quinpirole response in BALB/c mice [2]. The intra-locus coeruleus and intracerebroventricular injections of melanin-concentrating hormone and chronic injections of corticosterone increased immobility time in the forced swim test and decreased sucrose preference in the sucrose preference test. All these depressive-like behaviors were reversed by an intra-locus coeruleus microinjection of SNAP-94847 [3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 20 mg/mL (41.79 mM)
关键字: inhibit | Antidepressant | MCHR1 (GPR24) | Melanin concentrating hormone receptor 1 | SNAP 94847 | Inhibitor | SNAP94847 | anxiolytic | anxiety
相关产品: PSN 375963 | BMS-903452 | 2-Oleoylglycerol | GLPG1205 | Urotensin II, mouse TFA (9047-55-6 free base) | 6-OAU | AH-7614 | Setipiprant | GPR4 antagonist 1 | Fezagepras
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途