化合物ML216 T5413
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 1430213-30-1 | ¥823.00 | 询底价 |
1 mL | 1430213-30-1 | ¥496.00 | 询底价 |
100 mg | 1430213-30-1 | ¥3,362.00 | 询底价 |
50 mg | 1430213-30-1 | ¥2,515.00 | 询底价 |
25 mg | 1430213-30-1 | ¥1,658.00 | 询底价 |
5 mg | 1430213-30-1 | ¥448.00 | 询底价 |
Product Introduction
Bioactivity
英文名: ML216
描述: ML216 (CID-49852229) 是一种选择性、细胞渗透性的BLM 解旋酶抑制剂,具有抗肿瘤活性。它对BLMfull-length 和BLM636-1298的IC50分别为 2.98 μM 和 0.97 μM。
细胞实验: Cells were treated with BLM inhibitors at the indicated concentrations for up to 72 hr. At each time point, the WST-1 reagent (a pale tetrazolium derivative converted to an intensely-colored formazan product by the action of mitochondrial dehydrogenases) was added, and after a 4 hr incubation the plates were analyzed optically at 450 nm with a reference wavelength of 690 nm [2].
体外活性: ML216呈现细胞内活性,能够引起姊妹染色单体交换,增强aphidicolin的毒性,并在表达BLM的细胞中施展抗增殖活性,而在缺乏BLM的细胞中则不具此效应[2]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 5 mg/mL (13 mM)
关键字: helicase | ML 216 | WRN | DNA | ML216 | sister | inhibit | Anticancer | anti-proliferative | CID 49852229 | DNA/RNA Synthesis | Inhibitor | CID49852229 | chromatid | BLM | unwinding | toxicity | ML-216
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相关库: Anti-Aging Compound Library | Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | Covalent Inhibitor Library | Anti-Infection Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途