化合物JQ-1 carboxylic acid T5443

Product Introduction
Bioactivity


英文名: JQ-1 (carboxylic acid)

描述: JQ-1 (carboxylic acid) 是一种细胞渗透性 BRD4 抑制剂，对 BRD4(1) 和 BRD4(2) 的 IC50 分别为 77 和 33 nM。它是一种 (+)-JQ1 衍生物，可作为合成 PROTACs 的前体。

体外活性: JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins, blocking their interaction with acetylated histones[1],it has been used as a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis[2][3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 155 mg/mL (386.65 mM)


关键字: carboxylic acid | JQ 1 (carboxylic acid) | Epigenetic Reader Domain | JQ 1 | JQ-1 | Inhibitor | JQ1 (carboxylic acid) | polypeptide | JQ-1 (carboxylic acid) | JQ1 | chromatin | bromodomain | inhibit | remodeling

相关产品: HJB97 | Apabetalone | DCH36_06 | CDD-1102 HCl | Molibresib | Alobresib | AZD5153 6-Hydroxy-2-naphthoic acid | KG-501 | NP213 | IV-275

相关库: Anti-Aging Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Epigenetics Compound Library | PPI Inhibitor Library | Reprogramming Compound Library | Histone Modification Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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