化合物GSK3179106 T5491

Product Introduction
Bioactivity


英文名: GSK3179106

描述: GSK3179106 是选择性的、具有口服活性的RET 激酶抑制剂，对人和大鼠 RET 的 IC50 分别为 0.4 nM 和 0.2 nM。它能够减轻炎症后和应激引起的内脏超敏反应，对肠易激综合征具有潜在的应用价值。

体外活性: The effect of GSK3179106 on human and rat RET enzymatic activity and motesanib on human RET enzymatic activity was determined in an in vitro biochemical homogeneous time-resolved fluorescence (HTRF) assay.

体内活性: GSK3179106（3或10 mg/kg；口服；连续3.5天，每日两次）与给予乙酸灌肠并用安慰剂处理的大鼠相比，降低了内脏运动反应（VMR）。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (213.94 mM)


关键字: syndrome | post-inflammatory | visceral | GSK-3179106 | stress-induced | irritable | RET | Inhibitor | bowel | hypersensitivity | GSK 3179106 | orally | inhibit | IBS | GSK3179106

相关产品: AD80 | DUN73423 | BT-13 | TG101209 | AST 487 | Pralsetinib | Danusertib | RPI-1 | Treprostinil Sodium | Selpercatinib

相关库: Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Tyrosine Kinase Inhibitor Library | Apoptosis Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途