肉桂酸甲酯 T5552

Product Introduction
Bioactivity


英文名: Methyl cinnamate

描述: Methyl cinnamate 是花椒的有效成分，也是一种天然香料。它是一种防止食品褐变的酪氨酸酶抑制剂，具有抗菌活性。它通过由 CaMKK2-AMPK 信号途径介导的机制具有抗脂活性。

体外活性: At 1-3000 μmol/L, the E-isomer of methyl cinnamate (E-MC) concentration-dependently relaxed endothelium-intact aortic preparations that had been precontracted with phenylephrine (PHE; 1 μmol/L), with an IC50 value (geometric mean) of 877.6 μmol/L (95% confidence interval (CI) 784.1-982.2 μmol/L). Over the concentration range 1-3000 μmol/L, E-MC relaxed K(+) -induced contractions in mesenteric artery preparations (IC50 314.5 μmol/L; 95% CI 141.9-697.0 μmol/L) with greater potency than in aortic preparations (IC50 1144.7 μmol/L; 95% CI 823.2-1591.9 μmol/L).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : Insoluble
DMSO : 50 mg/mL (308.28 mM)


关键字: inhibit | Bacterial | Methyl 3-phenylpropenoate | CaMKK2 | 3T3-L1 | Methyl cinnamate | SREBP-1 | Inhibitor | activation | AMP-activated protein kinase | cells | PPARγ | natural | AMPK | flavor | preadipocytes | Tyrosinase | C/EBPα | antimicrobial

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相关库: Anti-Liver Cancer Compound Library | Oxidation-Reduction Compound Library | Tobacco Monomer Library | Neuronal Differentiation Compound Library | Chinese Pharmacopoeia Natural Product Library | Inhibitor Library | Kinase Inhibitor Library | Traditional Chinese Medicine Monomer Library | Anti-Bacterial Compound Library | Protease Inhibitor Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途