辅酶Q9 T5573

Product Introduction
Bioactivity


英文名: Coenzyme Q9

描述: Coenzyme Q9 (Ubiquinone 9) 是啮齿类动物泛醌的主要形式，是电子传递链中的一种双亲分子组分，具有内源性抗氧化剂的作用。它可减轻糖尿病引起的抗氧化防御机制的下降，改善左心室功能，减少心肌梗死面积和心肌细胞凋亡。

动物实验: Guinea pigs were randomly divided into three groups: groups I and II were fed CoQ 9 and CoQ10, respectively, for 30 days while group III served as control.?After 30 days, the guinea pigs were sacrificed and isolated hearts were perfused via working mode were subjected to 30 min ischemia followed by 2 h of reperfusion.?Cardioprotection was assessed by evaluating left ventricular function, ventricular arrhythmias, myocardial infarct size, and cardiomyocyte apoptosis.?Samples of hearts were examined for the presence of CoQ9 and CoQ10[1].

体外活性: Coenzyme Q9 were cardioprotective, as evidenced by their abilities to improve left ventricular performance and to reduce myocardial infarct size and cardiomyocyte apoptosis[1].

体内活性: Mutations in the gene that encodes Coenzyme Q9(CoQ9) are associated with encephalomyopathy and autosomal-recessive, neonatal-onset, primary CoQ10 deficiency.While in humans CoQ10 predominates, mice and C. elegans primarily rely on CoQ9 for electron transport through the mitochondrial respiratory chain and for antioxidant functions[2,3].

存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : < 1mg/ml (insoluble）


关键字: rodents | Coenzyme Q-9 | antioxidant | chain | transport | left | Coenzyme Q9 | Inhibitor | Ubiquinone9 | Coenzyme Q 9 | ventricular | Ubiquinone Q-9 | CoQ 9 | Endogenous Metabolite | amphipathic | Apoptosis | electron | inhibit | Ubiquinone Q 9 | endogenous | CoQ-9 | Ubiquinone-9

相关产品: ZM 336372 | D-Pantothenic acid hemicalcium salt | Isoalantolactone | GSK-J4 | Rhapontin | Serdemetan | Rapanone | ROC-325 | DB1976 | Lonidamine

相关库: Human Endogenous Metabolite Library | Oxidation-Reduction Compound Library | Anti-Metabolism Disease Compound Library | Human Endogenous Metabolite Compound Library Plus | Cuproptosis Compound Library | Mouse Metabolite Compound Library | Gut Microbial Metabolite Library | Covalent Inhibitor Library | Bioactive Compound Library | Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途