化合物ZT-12-037-01 T5597

Product Introduction
Bioactivity


英文名: ZT-12-037-01

描述: ZT-12-037-01 是一种 ATP 竞争性 STK19 抑制剂，对 STK19 (WT) 和 STK19 (D89N) 的 IC50 值分别为 23.96 和 27.94 nM

动物实验: ZT-12-037-01 (injection subcutaneously; 25-50 mg/kg; once daily; 21 days) inhibits growth of SK-MEL-2 xenograft melanoma and the sections of tumors indicates induction of apoptosis by increasing cleaved caspase-3.

体外活性: ZT-12-037-01 显著抑制突变型NRAS-STK19驱动的黑色素细胞群体形成和增殖。

体内活性: ZT-12-037-01 作为一种特异性的 STK19 靶向抑制剂，能有效阻断致癌的 NRAS 驱动的黑色素细胞恶性转化和体内的黑色素瘤生长。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 41 mg/mL (106.36 mM)


关键字: inhibit | ZT 12 037 01 | ZT1203701 | Ras | Inhibitor | ZT-12-037-01

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相关库: Anti-Liver Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Anti-Ovarian Cancer Compound Library | GPCR Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Highly Selective Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途