乙酸香叶酯 T5607

Product Introduction
Bioactivity


英文名: Geranyl acetate

描述: Geranyl acetate 是一种由香叶醇衍生而来的无环单萜烯酯，可诱导细胞凋亡。它具有香味，被广泛用于化妆品行业。

细胞实验: The antiproliferative activity was determined by MTT assay. Apoptosis was assessed by DAPI staining and DNA damage was checked by comet assay. The cell cycle analysis was carried out by flow cytometry and protein expression was examined by western blotting.[1].

体外活性: Studies on the antifungal activity especially Microsporum gypsum, Trichophyton vercossum and Candida tropicalis showed that geranyl acetate, its epoxide and hydroperoxide derivatives have good antifungal action[1].Geranyl acetate exhibited significant anticancer activity against colo-205 cancer cell line with IC50 values of 30 μM . To find out the underlying mechanism, DAPI staining was carried out and it was observed that both the monoterpenes, geraniol and geranyl acetate, induced apoptosis in colo-205 cells. The apoptosis was also associated with upregulation of Bax and downregulation of Bcl-2 expressions, indicative of mitochondrial apoptosis. Moreover, this monoterpenes could trigger DNA damage and G2/M cell cycle arrest in colo-205 cells[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (127.36 mM)


关键字: Geranyl acetate | Apoptosis | Inhibitor | Geranyl Acetate | inhibit | Geranyl

相关产品: Capsaicin | JIB-04 | Torkinib | Suberoyl bis-hydroxamic acid | MitoBloCK-6 | Tofacitinib | Alda-1 | Celosin K | STM2457 | Nocodazole

相关库: Tobacco Monomer Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Chinese Pharmacopoeia Natural Product Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Miao medicine Compound Library | Traditional Mongolian Medicine Compound Library | Bioactive Compound Library | Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途