4-肉桂苯酚 T5628

Product Introduction
Bioactivity


英文名: p-cumylphenol

描述: p-cumylphenol 可治疗新生大鼠肾小管囊肿形成。

动物实验: Fifteen animals per sex were treated orally with 300 mg/kg/day of p-cumylphenol for up to 18 days from postnatal day (PND) 4 and were sacrificed on PNDs 8, 12, 19 and 22 and after a 7 day recovery period. On PNDs 8 and 12, slight dilatation of the collecting ducts was frequently observed in the medulla and slight papillary necrosis was also noted in some cases. These dilated collecting ducts were lined with slightly hyperplastic epithelial cells. On PNDs 19 and 22, multiple large cystic changes arising from the collecting ducts in the outer medulla were seen.

体内活性: P-cumylphenol induced multiple renal cysts that developed in the collecting ducts of the outer medulla in neonatal rats, and it is suggested that epithelial cell proliferation may play some roles in the induction of cystic lesions.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 22.5 mg/mL (105.99 mM)


关键字: pcumylphenol | p cumylphenol | p-cumylphenol

相关库: Bioactive Compounds Library Max | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途