化合物Belvarafenib T5634

Product Introduction
Bioactivity


英文名: Belvarafenib

描述: Belvarafenib 是一种有效的泛 RAF 抑制剂，具有抗肿瘤活性，对 B-RAF、B-RAFv600E 和 C-RAF 的 IC50值分别为 56、7 和 5 nM。

体外活性: Belvarafenib ?is a potent and pan RAF inhibitor with antineoplastic activity.?The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.?It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (52.2 mM)


关键字: RG-6185 | inhibit | GDC-5573 | HM 95573 | GDC 5573 | Inhibitor | RG6185 | RG 6185 | HM95573 | HM-95573 | Belvarafenib | GDC5573 | Raf kinases | Raf

相关产品: LY2452473 | CCT241161 | SGX-523 | GSK2008607 | K-Ras(G12C) Inhibitor 6 | GNE-9815 | Locostatin | B-Raf IN 16 | B-Raf IN 11 | PROTAC BRAF-V600E degrader-1

相关库: Drug Repurposing Compound Library | Anti-Prostate Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途