化合物Adavivint (SM04690) T5636

Product Introduction
Bioactivity


英文名: Adavivint

描述: Adavivint (Adavivint (SM04690)) (SM04690) 是选择性的典型的Wnt 信号通路抑制剂，在 SW480 细胞中，用高通量 TCF/LEF 报告基因实验，测得EC50=19.5 nM。

动物实验: A high-throughput screen was performed using a cell-based reporter assay for Wnt pathway activity to develop a small molecule designated SM04690. Its properties were evaluated in bone-marrow-derived human mesenchymal stem cells (hMSCs) to assess chondrocyte differentiation and effects on cartilage catabolism by immunocytochemistry and gene expression, and glycosaminoglycan breakdown. In vivo effects of SM04690 on Wnt signaling, cartilage regeneration and protection were measured using biochemical and histopathological techniques in a rodent acute cruciate ligament tear and partial medial meniscectomy (ACLT + pMMx) OA model.

体内活性: Adavivint (SM04690) is a?novel Wnt pathway inhibitor, for the treatment of moderate to severe osteoarthritis of the knee.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Slightly soluble


关键字: Wnt | Lorecivivint | Adavivint | SM 04690 | inhibit | Inhibitor | SM04690 | SM-04690

相关产品: TNIK-IN-5 | exo-IWR-1 | ZW4864 free base | Pyrvinium pamoate | KY02111 | YW2036 | Nesuparib | TNKS-2-IN-2 | TNIK-IN-3 | MSAB

相关库: Drug Repurposing Compound Library | Wnt/Hedgehog/Notch Compound Library | ReFRAME Related Library | Anti-Cancer Drug Library | Clinical Compound Library | Neural Regeneration Compound Library | Anti-Ovarian Cancer Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途