橙花醇 T5645
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 106-25-2 | ¥968.00 | 询底价 |
10 mg | 106-25-2 | ¥393.00 | 询底价 |
25 mg | 106-25-2 | ¥659.00 | 询底价 |
1 mL | 106-25-2 | ¥258.00 | 询底价 |
5 mg | 106-25-2 | ¥255.00 | 询底价 |
500 mg | 106-25-2 | ¥3,590.00 | 询底价 |
100 mg | 106-25-2 | ¥1,430.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Nerol
描述: Nerol (Neryl alcohol) 是橙花油的一种单萜, 它通过增强 Ca2+和ROS 来触发线粒体功能障碍并诱导凋亡,具有抗真菌活性。它可减轻哺乳动物心脏中哇巴因引发的心律失常的严重程度。
动物实验: Guinea pigs were sacrificed by decapitation and hearts were removed and isolated left atrium mounted vertically in an organ baths containing Tyrode's solution of the following composition (mM): NaCl 120, KCl 2.7, MgCl2 0.9, NaHCO3 11.9, CaCl2 1.37, glucose 5.5, NaH2PO4 0.4, pH 7.4. The atria preparations were subsequently connected to Grass FI'-03 force displacement transducers to record changes in atrial contractile force. Each muscle was stretched to the length at which contractile force was maximal (1.0 gf). The atria were electrically paced at 1 Hz with pulses of 1.5 ms duration and stimulated by 70 V pulses. All preparations were allowed to equilibrate for 30 min until complete mechanical stabilization had been achieved. Nerol ( 97%) was freshly solubilized in 0.5% DMSO and cumulatively added to bath chambers. After each observation, muscles were washed several times and allowed to recover for 30 minutes until their mechanical function completely returned to control values. DMSO at this concentration did not show any significant effect on the variables measured (data not shown, n = 5).
体内活性: Nerol主要通过阻断L型Ca2+通道减少Ca2+的流入,从而减轻了哺乳动物心脏中ouabain引发的心律失常的严重程度。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45 mg/mL (291.73 mM)
关键字: Antifungal | inhibit | Fungal | Reactive Oxygen Species | Inhibitor | mitochondrial | Nerol | Calcium | dysfunction | Apoptosis | NEL | Endogenous Metabolite | ROS | Mitochondrial Metabolism
相关产品: Camptothecin | MY-1076 | Isoalantolactone | AOH1160 | GSK-J4 | kauran-16,17-diol | Anticancer agent 106 | BML-210 | 3-Dehydrotrametenolic acid | Unesbulin
相关库: Anti-Aging Compound Library | PBCRBS Traditional Chinese Medicine Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Tobacco Monomer Library | NF-κB Signaling Compound Library | Bioactive Compounds Library Max | Traditional Chinese Medicine Monomer Library | Anti-Fungal Compound Library | Miao medicine Compound Library | Anti-Infection Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途