化合物(Z)-SU4312 T5676
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 90828-16-3 | ¥6,880.00 | 询底价 |
100 mg | 90828-16-3 | ¥12,500.00 | 询底价 |
1 mL | 90828-16-3 | ¥2,580.00 | 询底价 |
5 mg | 90828-16-3 | ¥2,920.00 | 询底价 |
10 mg | 90828-16-3 | ¥4,320.00 | 询底价 |
2 mg | 90828-16-3 | ¥1,930.00 | 询底价 |
50 mg | 90828-16-3 | ¥9,330.00 | 询底价 |
1 mg | 90828-16-3 | ¥1,290.00 | 询底价 |
Product Introduction
Bioactivity
英文名: (Z)-SU4312
描述: (Z)-SU4312 是 MAO-B 和 NOS 的抑制剂(IC50 值分别为 0.2 μM 和 19.0μM)。
动物实验: MPP(+) -treated neurons and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated zebrafish were used to study neuroprotection by?(Z)-SU4312. NOS activity was assayed in vitro to examine direct interactions between?SU4312?and NOS isoforms[1].
体外活性: (Z)-SU4312 unexpectedly prevented MPP(+) -induced neuronal apoptosis in vitro and decreased MPTP-induced loss of dopaminergic neurons, reduced expression of mRNA for tyrosine hydroxylase and impaired swimming behaviour in zebrafish.?(Z)-SU4312 exhibited non-competitive inhibition of purified neuronal NOS (nNOS) with an IC(50) value of 19.0?μM but showed little or no effects on inducible and endothelial NOS. Molecular docking simulations suggested an interaction between (Z)-SU4312 and the haem group within the active centre of nNOS[1].
体内活性: (Z)-SU4312 was able to selectively inhibit monoamine oxidase-B (MAO-B) activity both in vitro and in vivo, with an IC50 value of 0.2 μM.(Z)-SU43122 provides therapeutic benefits in cellular and animal models of PD, possibly through multiple mechanisms including enhancement of MEF2D through the activation of PI3-K/Akt pathway, maintenance of mitochondrial biogenesis and inhibition of MAO-B activity.?(Z)-SU4312 thus may be an effective drug candidate for the prevention or even modification of the pathological processes of PD[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 30 mg/mL (113.5 mM)
关键字: (Z)-SU-4312 | (Z)SU4312 | SU4312 | SU 4312 | SU-4312 | (Z) SU4312
相关产品: Moclobemide | Cassiaside B2 | Brofaromine | hMAO-B-IN-32 | Hydroxyamine hydrochloride | Isatin | Paeonol | Modaline sulfate | Dihydroevocarpine | Vafidemstat
相关库: Anti-Neurodegenerative Disease Compound Library | Anti-Parkinson's Disease Compound Library | Mitochondria-Targeted Compound Library | Anti-Metabolism Disease Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Nonsteroidal Anti-Inflammatory Compound Library | Covalent Inhibitor Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途