芦荟苷 T5680
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 8015-61-0 | ¥1,230.00 | 询底价 |
500 mg | 8015-61-0 | ¥9,390.00 | 询底价 |
25 mg | 8015-61-0 | ¥2,080.00 | 询底价 |
50 mg | 8015-61-0 | ¥3,130.00 | 询底价 |
1 mL | 8015-61-0 | ¥898.00 | 询底价 |
100 mg | 8015-61-0 | ¥4,480.00 | 询底价 |
1 mg | 8015-61-0 | ¥413.00 | 询底价 |
5 mg | 8015-61-0 | ¥913.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Aloin(mixture of A&B)
描述: Aloin (mixture of A&B) 是一种从芦荟中分离出来的蒽醌衍生物。它是刺激性粒细胞基质金属蛋白酶的有效抑制剂。它具有多种生物活性,如抗炎、抗菌、抗真菌、抗氧化、抗肿瘤、抗糖尿病和免疫活性。
动物实验: Saliva was collected from volunteers to determine IL-1β and IL-8 levels. Samples from volunteers were divided into two groups: those with low and those with high IL-1β levels. KB cells were stimulated with IL-1β or saliva with or without IL-1 receptor agonist or specific mitogen-activated protein kinase (MAPK) inhibitors. IL-8 production was measured by enzyme-linked immunosorbent assay (ELISA). MAPK protein expression involved in IL-1β-induced IL-8 secretion was detected by Western blot. KB cells were pretreated with?aloin, and its effect on IL-1β-induced IL-8 production was examined by ELISA and Western blot analysis[1].
体外活性: Clostridium histolyticum collagenase (ChC) results dose-dependently inhibited by aloe gel and the activity-guided fractionation led to an active fraction enriched in phenolics and aloins.?Aloins have been shown to be able to bind and to inhibit ChC reversibly and non-competitively.?Aloe gel and aloins are also effective inhibitors of stimulated granulocyte matrix metalloproteinases (MMPs)[1].
体内活性: Aloin effectively inhibits salivary IL-1β-induced IL-8 production by mitigating the p38 and ERK pathway. Therefore, aloin may be a good candidate for modulating oral inflammatory diseases[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (119.51 mM)
关键字: inhibit | Matrix metalloproteinases | Bacterial | MMP | Aloin(mixture of A&B) | Inhibitor | Fungal
相关产品: MMP3 inhibitor 1 | T-26c | Norepinephrine | TAPI1 | S 3304 | Ginsenoside F4 | 2,3-Dihydrohinokiflavone | Polygalacic acid | Astragaloside IV | TP0556351
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途