醉茄素A T5687

Product Introduction
Bioactivity


英文名: WITHAFERIN A

描述: Withaferin A 是从南非醉茄中分离到的一种甾体内酯，是内皮蛋白 C 受体脱落抑制剂，可以抑制NF-kB 的活性，具有抗炎，抗肿瘤等作用。它是一种新型 NFkappaB 抑制剂，有望成为治疗各种炎症性疾病和癌症的新型抗炎药。

细胞实验: L929sA cells were co-treated with WITHAFERIN A and DTT for 1 h, and then TNF-induced NFκB activation was examined.

动物实验: Mice are injected subcutaneously with zymosan in the footpad, and swelling is determined at several time points after the injection. Pretreatment with WITHAFERIN A(intraperitoneal) was performed to evaluate anti-inflammatory effects, whereas DEX (intraperitoneal) was chosen as a positive control. the mean of the differences between the zymosan-treated and untreated footpad for all the three groups. Both DEX.

体外活性: WITHAFERIN A 有效抑制了NFkappaB的激活，它通过一个对硫醇烷基化敏感的氧化还原机制，阻止了肿瘤坏死因子诱导的IkappaB激酶β的激活。

体内活性: WITHAFERIN A在体内显示抗炎性质——因为NFκB是炎症信号通路中的关键参与者，且WITHAFERIN A能抑制NFκB的激活。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 27.5 mg/mL (58.44 mM)


关键字: NF-κB | Nuclear factor-κB | WITHAFERIN A | Inhibitor | Ferroptosis | Nuclear factor-kappaB | inhibit

相关产品: Rosiglitazone | Artesunate | Baicalein | L-Glutamine | Acetylcysteine | TBHQ | Brusatol | Curcumin | MMRi62 | Butylhydroxyanisole

相关库: Cell Cycle Compound Library | NF-κB Signaling Compound Library | Anti-Lung Cancer Compound Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | NO PAINS Compound Library | Natural Product Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途