波尔定 T5720

Product Introduction
Bioactivity


英文名: Boldine

描述: Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) 是一种阿扑吗啡异喹啉生物碱，从山苍子根中提取获得，具有抗氧化、抗炎和细胞保护的活性。它能够抑制破骨细胞生成，并利用下调 OPG/RANKL/RANK 信号途径，改善骨破坏。它可用于研究类风湿性关节炎。

细胞实验: Sulforhodamine B assay, Tetrazolium reduction assay, Flow Cytometry Analysis, Ecto-5'-nucleotidase activity and Western blot assay were performed[1].

动物实验: Vascular reactivity was studied in mouse aortas from db/db diabetic and normal mice.?Reactive oxygen species (ROS) production, angiotensin AT1 receptor localization and protein expression of oxidative stress markers in the vascular wall were evaluated by dihydroethidium fluorescence, lucigenin enhanced-chemiluminescence, immunohistochemistry and Western blot respectively.?Primary cultures of mouse aortic endothelial cells, exposed to high concentrations of glucose (30?mmol L(-1) ) were also used[2].

体外活性: Boldine was able to reduce cell viability and cell proliferation in T24 cells.?In addition, boldine arrests the cell cycle at G2/M-phase and cause cell death by apoptosis.?Boldine-induced inhibition of cell growth and cell cycle arrest appears to be linked to inactivation of extracellular signal-regulated kinase protein (ERK).?Additionally, the efficacy of boldine in apoptosis-induced in T24 cells is correlated with modulation of AKT (inactivation) and glycogen synthase kinase-3β (GSK-3β) (activation) proteins[1].

体内活性: Boldine reduced oxidative stress and improved endothelium-dependent relaxation in aortas of diabetic mice largely through inhibiting ROS overproduction associated with Ang II-mediated BMP4-dependent mechanisms[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 65 mg/mL (198.55 mM)


关键字: Boldine | inhibit | Inhibitor

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途