L-白雀木醇 T5729

Product Introduction
Bioactivity


英文名: L-quebrachitol

描述: L-Quebrachitol 是一种从多种植物中分离得到的天然产物，能够触发 BMP-2 反应以及 Runx2、MAPK 和 Wnt/β-catenin 信号通路，诱导成骨细胞生成。

细胞实验: The total RNA from cells treated with l-quebrachitol was extracted using the TriPure Isolation Reagent .RNA (1 μg) was reverse transcribed using the Transcriptor First Strand cDNA Synthesis Kit to cDNA.The qRT-PCR analysis was performed using the EvaGreen HRM Mix .GAPDH was used as an internal control.The relative expression ratio was calculated using the 2^?△△Ct method.

体外活性: L-quebrachitol significantly promotes proliferation and cell DNA synthesis. It also enhances mineralization accompanied by increases in mRNA expression of bone matrix proteins including alkaline phosphatase (ALP), collagen type I (ColI), osteocalcin (OCN), and osteopontin (OPN). In addition, l-quebrachitol upregulates the mRNA and protein expression of bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2), while down-regulating the receptor activator of the nuclear factor-κB ligand (RANKL) mRNA level. Moreover, the expression of regulatory genes associated with the mitogen-activated protein kinase (MAPK) and wingless-type MMTV integration site (Wnt)/β-catenin signaling pathways are also upregulated.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 22.5 mg/mL (115.87 mM)


关键字: Beta catenin | Wnt | L quebrachitol | Inhibitor | L-quebrachitol | Lquebrachitol | L-Quebrachitol | inhibit | β-catenin

相关产品: ICG001 | WAY-262611 | Excisanin A | Astragaloside I | TNIK-IN-7 | K-756 | TNKS-2-IN-1 | iCRT-5 | NRX-103094 | KY1220

相关库: Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | Anti-Cancer Metabolism Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Reprogramming Compound Library | Natural Product Library

L-白雀木醇 T5729信息由TargetMol中国为您提供，如您想了解更多关于L-白雀木醇 T5729报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途