1,3-二咖啡酰奎宁酸 T5736

Product Introduction
Bioactivity


英文名: 1,3-Dicaffeoylquinic acid

描述: 1,3-Dicaffeoylquinic acid (CYNARIN) 是一种咖啡酰奎宁酸衍生物，具有抗氧化、自由基清除作用。

动物实验: The neuroprotective effects of 1,5-DQA against amyloid β(1-42) (Aβ(42))-induced neurotoxicity in primary neuronal culture. To evaluate the neuroprotective effects of 1,5-DQA, primary cultured cortical neurons from neonate rats were pretreated with 1,5-DQA for 2 hours and then treated with 40 μmol/L Aβ(42) for 6 hours. Cell counting kit-8, Hoechst staining and Western blotting were used for detecting the protective mechanism. Comparisons between two groups were evaluated by independent t test, and multiple comparisons were analyzed by one-way analysis of variance (ANOVA).

体内活性: CYNARIN have neuroprotective effects.CYNARIN prevents Aβ(42)-induced neurotoxicity through the activation of PI3K/Akt followed by the stimulation of Trk A, then the inhibition of GSK3β as well as the modulation of Bcl-2/Bax.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 23 mg/mL (44.53 mM)


关键字: Phosphoinositide 3-kinase | 1,3 Dicaffeoylquinic acid | PI3K | Akt | inhibit | Protein kinase B | Inhibitor | 1,3Dicaffeoylquinic acid | PKB | 1,3-Dicaffeoylquinic acid | Reactive Oxygen Species

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相关库: PI3K-AKT-mTOR Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Glycometabolism Compound Library | Anti-Liver Cancer Compound Library | Glutamine Metabolism Compound Library | Kinase Inhibitor Library | Traditional Chinese Medicine Monomer Library | Miao medicine Compound Library | Reprogramming Compound Library | Stem Cell Differentiation Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途