异紫花前胡内酯 T5759

Product Introduction
Bioactivity


英文名: S-(+)-Marmesin

描述: S-(+)-Marmesin (marmesin) 是一种从木橘成熟树皮中分离得到的香豆素，具有 COX-2/5-LOX 双重抑制活性。

体外活性: Marmesin treatment abrogated VEGF-A-induced endothelial cell migration, invasion and capillary-like structure formation in vitro as well as angiogenic sprouting ex vivo. These anti-angiogenic activities of marmesin were mediated through inactivation of VEGF-A-stimulated signaling pathways, and down-regulation of cell surface signaling molecules including VEGF receptor-2, human epidermal growth factor receptor-2, integrin β1 and integrin-liked kinase[1].

体内活性: Marmesin inhibits colony formation and induces apoptosis dose-dependently.Marmesin treatment triggered upregulation of Bax and downregulation of Bcl-2 causing significant increase in the Bax/Bcl-2 ratio, marmesin could also induce ROS mediated alterations in mitochondrial membrane potential. Additionally, marmesin induced G2/M cell cycle arrest and significantly inhibited cell migration potential of leukemia cells at the IC50. Remarkably, marmesin prevent tumor growth significantly in vivo at the dosage of 30 mg/kg in vivo. These results strongly indicate that marmesin may prove to be a novel anticancer lead for the management of leukemia[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 2 mg/mL (8.12 mM)


关键字: COX | Lipoxygenase | S-Marmesin | LOX | S(+)Marmesin | Cyclooxygenase | inhibit | Inhibitor | S (+) Marmesin

相关产品: COX-2/15-LOX-IN-2 | Pinusolide | ALOX15-IN-2 | Linetastine | Lycopodine | 5-LOX inhibitor | Efletirizine | COX-2/15-LOX-IN-4 | BW 755C | 4-MMPB

相关库: PBCRBS Traditional Chinese Medicine Compound Library | Angiogenesis related Compound Library | Anti-Metabolism Disease Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Colorectal Cancer Compound Library | Traditional Chinese Medicine Monomer Library | Lipid Metabolism Compound Library | RO5 Drug-like Natural Product Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途