三七皂甙 Ft1 T5761
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 155683-00-4 | ¥1,319.00 | 询底价 |
10 mg | 155683-00-4 | ¥835.00 | 询底价 |
2 mg | 155683-00-4 | ¥398.00 | 询底价 |
1 mL | 155683-00-4 | ¥797.00 | 询底价 |
5 mg | 155683-00-4 | ¥667.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Notoginsenoside Ft1
描述: Notoginsenoside Ft1 是一种植物分离的三七皂苷,具有刺激血管生成的作用。
激酶实验: Platelet aggregation was analysed using a platelet aggregometer. Prothrombin time, activated partial thromboplastin time and thrombin time were measured using a blood coagulation analyser, which was further corroborated with bleeding time and thrombotic assays[2].
体外活性: Notoginsenoside Ft1 (Ft1) is a novel stimulator of angiogenesis. Ft1 induces proliferation, migration, and tube formation in cultured human umbilical vein endothelial cells (HUVECs). Ft1 increases translocalization of hypoxia-inducible factor-1α (HIF-1α) from cytoplasm to nuclei, where it binds to the vascular endothelial growth factor (VEGF) promoter, increasing the expression of VEGF mRNA and the subsequent secretion of the growth factor. Ft1 induces the activation of PI3K/AKT and Raf/MEK/ERK signaling pathways. Pharmacological inhibition with LY294002, wortmanin or PD98059 reduces Ft1-induced angiogenesis, indicating the important role played by these pathways. In addition, Ft1 induces phosphorylation of the mammalian target of rapamycin (mTOR), and siRNA-mediated mTOR knockdown decreases tube formation, proliferation, transport of HIF-1α into nuclei and VEGF mRNA expression in response to Ft1[1].Among the saponins examined, Notoginsenoside Ft1(Ft1) was the most potent procoagulant and induced dose-dependent platelet aggregation. Ft1 reduced plasma coagulation indexes, decreased tail bleeding time and increased thrombogenesis. Moreover, it potentiated ADP-induced platelet aggregation and increased cytosolic Ca(2+) accumulation, effects that were attenuated by clopidogrel[2].
存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 25 mg/mL (27.26 mM)
关键字: inhibit | Notoginsenoside Ft 1 | Inhibitor | Notoginsenoside Ft-1 | Notoginsenoside Ft1
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相关库: PBCRBS Traditional Chinese Medicine Compound Library | Terpene Natural Product Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Chinese Pharmacopoeia Natural Product Library | Epigenetics Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Traditional Mongolian Medicine Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途