灰毡毛忍冬次皂苷乙 T5787

Product Introduction
Bioactivity


英文名: Macranthoside B

描述: Macranthoside B 是一种从金银花中分离出来的天然产物，具有抗菌活性。

细胞实验: The anticancer effect of Macranthoside B both in vitro and in vivo using cell proliferation assays and xenograft tumor growth assays. Macranthoside B inhibits the proliferation of various kinds of cancer cells with IC(50) values in the range of 10-20 microM. Moreover, the volume and weight of xenograft tumors in nude mice treated with 5mg/kgMacranthoside B were decreased remarkably compared to those of the vehicle control group. Furthermore, DAPI staining and flow cytometry analysis with Annexin V/PI double staining revealed that more apoptotic cells were observed following Macranthoside B treatment. In addition, degradation of PARP (poly-ADP-ribose polymerase), and activation of the caspase cascade for intrinsic pathways were observed. The expression of Bcl-2 protein decreased and the protein level of Bax increased which leading to an increase of the Bax/Bcl-2 ratio. Macranthoside B exhibited strong anti-tumor effect and mitochondrion-mediated apoptosis induction involved in it[1].

体外活性: Macranthoside B，一种从金银花 (Lonicera macranthoides) 提取的羽扇豆皂甙，具有体外和体内抗肿瘤活性[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Slightly soluble


关键字: Bacterial | Inhibitor | inhibit | Macranthoside B

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