大戟因子L2 T5798
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 218916-51-9 | ¥475.00 | 询底价 |
25 mg | 218916-51-9 | ¥2,830.00 | 询底价 |
100 mg | 218916-51-9 | ¥5,890.00 | 询底价 |
5 mg | 218916-51-9 | ¥1,130.00 | 询底价 |
10 mg | 218916-51-9 | ¥1,680.00 | 询底价 |
1 mL | 218916-51-9 | ¥1,810.00 | 询底价 |
50 mg | 218916-51-9 | ¥4,190.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Euphorbia Factor L2
描述: Euphorbia Factor L2 是从大戟种子中分离得到的一种赤藓烷二萜,显示强烈的细胞毒性并通过线粒体途径诱导细胞凋亡,具有抗癌活性。
体内活性: Euphorbia factor L2 (EFL2) on LPS-induced ALI in mice, where EFL2 attenuated pathological alterations in the lung and improved survival. Significant suppression of the recruitment and transmigration of inflammatory cells, specifically neutrophils, by 40?mg/kg of EFL2 was observed. EFL2 exerted potent anti-inflammatory effects by decreasing the levels of interleukin-1β (IL-1 β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF- α), interleukin-8 (IL-8) and myeloperoxidase (MPO) in the lung and bronchioalveolar lavage fluid. Consistent with the findings in vivo, EFL2 also showed robust inhibitory effects on the production of IL-1 β, IL-6, TNF- α and IL-8 released from LPS-stimulated RAW264.7 cells in vitro. Interestingly, this effect appeared to be mediated by EFL2's inhibition of NF-κB signaling activation, but not the MAPK pathway. Not only phosphorylation of IKK α/β and IκBα was down-regulated, p65 translocation and its DNA-binding activity were also significantly suppressed by EFL2. Moreover, overexpression of p65 reversed the inhibitory effect of EFL2 in LPS-induced NF-κB activation and cytokines production. The observed anti-inflammatory bioactivity of EFL2 indicates its potential as a drug development candidate, particularly for LPS-mediated disorders of inflammation[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 12 mg/mL (18.67 mM)
关键字: Inhibitor | Euphorbia Factor L 2 | Apoptosis | Euphorbia Factor L-2 | inhibit | Euphorbia Factor L2
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途