水甘草碱盐酸盐 T5810

Product Introduction
Bioactivity


英文名: TABERSONINE HYDROCHLORIDE

描述: Tabersonine hydrochloride 是分离自蔷薇中的一种吲哚类生物碱，具有抗炎活性，可用于 ALI/ARDS 的研究。Tabersonine 能破坏 Aβ(1-42) 的聚合和改善 Aβ 聚集诱导的细胞毒性。

体内活性: TABERSONINE HYDROCHLORIDE is an indole alkaloid mainly isolated from Catharanthus roseus, and a potential drug candidate for treatment of cancer and Alzheimer's disease (AD), however, its anti-inflammatory effect has not been revealed.TABERSONINE HYDROCHLORIDE ameliorated lipopolysaccharides (LPS)-induced ALI in vivo and inhibited LPS-mediated macrophage activation in vitro. By using murine ALI model, we found that TABERSONINE HYDROCHLORIDE significantly attenuated LPS-induced pathological injury in the lung. TABERSONINE HYDROCHLORIDE also inhibited LPS-mediated neutrophil infiltration, elevation of MPO activity and the production of TNF-α, IL-6 and IL-1β. Furthermore, TABERSONINE HYDROCHLORIDE inhibited LPS-induced the production of pro-inflammatory mediators such as iNOS, NO and cytokines by suppressing NF-κB and p38 MAPK/MK2 signaling cascades. TABERSONINE HYDROCHLORIDE HYDROCHLORIDE reduced the K63-linked polyubiquitination of TRAF6. Taken together,TABERSONINE HYDROCHLORIDE has anti-inflammatory activities in vitro and in vivo, and is a potential therapeutic candidate for the treatment of ALI/ARDS[1].

存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 40 mg/mL (107.27 mM)


关键字: TABERSONINE HYDROCHLORIDE | Tabersonine | TABERSONINE Hydrochloride | inhibit | Inhibitor | LI/ARDS | Aβ(1-42)

相关产品: β-Amyloid (1-42), human | Anatabine | 1H-Indole-3-carboxylic acid, 5-[2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propoxy]-2-methyl-1-(4-methylphenyl)-, ethyl ester | β-Amyloid (25-35) | Pinostrobin | β-Amyrin | Begacestat | β-Amyloid (31-35) | Latrepirdine dihydrochloride | Ginsenoside Rg2

相关库: Anti-Neurodegenerative Disease Compound Library | Selected Plant-Sourced Compound Library | Covalent Natural Product Library | Bioactive Compounds Library Max | Inhibitor Library | Alkaloid Natural Product Library | Traditional Chinese Medicine Monomer Library | NO PAINS Compound Library | Natural Product Library | Bioactive Compound Library

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