化合物Cravatt Reagent T5815

Product Introduction
Bioactivity


英文名: MJN110

描述: MJN110 (Cravatt Reagent) 是选择性的、口服具有活性的单酰基甘油脂肪酶 (MAGL) 抑制剂，对 hMAGL 和 2-花生四烯酸甘油酯 (2-AG) 的IC50分别为 9.1 nM 和 2.1 nM。它具有阿片类药物保护作用，具有显著的抗痛觉过敏活性。

动物实验: For repeated administration experiments, mice were given vehicle, 0.0818 mg/kg MJN110, 0.469 or 10 mg/kg morphine, or a combination of 0.0818 mg/kg Cravatt Reagent?and 0.469 mg/kg morphine twice?daily for 5.5 days.?Then, mice underwent behavioral testing on day 6.?The combination of 0.0818 mg/kg MJN110 and 0.469 mg/kg morphine produced significant antinociceptive effects.

体内活性: The Selective Monoacylglycerol Lipase Inhibitor Cravatt Reagent Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 27.5 mg/mL (59.48 mM)


关键字: MJN 110 | MAGL | Inhibitor | Monoacylglycerol lipase | MJN-110 | MJN110 | inhibit

相关产品: Y-320 | WWL70 | Atglistatin | URB602 | ABX-1431 | NG-497 | PF-06795071 | NF-1819 | JW 642 | Beta-Sitosterol

相关库: Anti-Metabolism Disease Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Obesity Compound Library | Lipid Metabolism Compound Library | Metabolism Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途