化合物Rapastinel Trifluoroacetate T5819

Product Introduction
Bioactivity


英文名: Rapastinel Trifluoroacetate

描述: Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) 是一种 NMDA 受体调节剂，具有甘氨酸位点部分激动剂性质，有研究抑郁症的潜力。

动物实验: C57BL/6J mice given a single dose or subchronic ketamine (30 mg/kg.i.p.) showed acute or persistent deficits in NOR, respectively.?Acute i.v. rapastinel (1.0 mg/kg), did not induce NOR deficit.?Pre-treatment with Rapastinel Trifluoroacetate?significantly prevented acute ketamine-induced NOR deficit.?Rapastinel Trifluoroacetate?(1.0 mg/kg, but not 0.3 mg/kg, iv) significantly reversed both subchronic ketamine- and subchronic PCP-induced NOR deficits.?Rapastinel Trifluoroacetate?also potentiated the atypical antipsychotic drug with antidepressant properties, lurasidone, to restore NOR in subchronic ketamine-treated mice.?Unlike ketamine,Rapastinel Trifluoroacetate?does not induce a declarative memory deficit in mice, and can prevent or reverse the ketamine-induced NOR deficit.?Further study is required to determine if these differences translate during clinical use of ketamine and rapastinel as fast acting antidepressant drugs and if rapastinel could have non-ionotropic effects as an add-on therapy with antipsychotic/antidepressant medications.

体内活性: Rapastinel Trifluoroacetate, a tetrapeptide (Thr-Pro-Pro-Thr-amide), has been reported to have fast acting antidepressant properties in man based upon its N-methyl-D-aspartate receptor (NMDAR) glycine site functional partial agonism.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 125 mg/mL (236.97 mM)


关键字: GLYX 13 | inhibit | GLYX13 | GLYX-13 | Inhibitor | Rapastinel | GLYX13 Trifluoroacetate | Ionotropic glutamate receptors | Rapastinel Trifluoroacetate | iGluR | GLYX 13 Trifluoroacetate

相关产品: Glypromate | NMDAR/TRPM4-IN-2 | SDZ 220-040 | Dizocilpine | Riluzole | LY339434 HCl | NKH477 | AV-101 | Gacyclidine | D-Serine

相关库: Ion Channel Inhibitor Library | Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | Antidepressant Compound Library | Anti-Cancer Clinical Compound Library | Anti-Alzheimer's Disease Compound Library

化合物Rapastinel Trifluoroacetate T5819信息由TargetMol中国为您提供，如您想了解更多关于化合物Rapastinel Trifluoroacetate T5819报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途