化合物BC-1215 T5821
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 1507370-20-8 | ¥546.00 | 询底价 |
1 mg | 1507370-20-8 | ¥221.00 | 询底价 |
10 mg | 1507370-20-8 | ¥795.00 | 询底价 |
50 mg | 1507370-20-8 | ¥1,830.00 | 询底价 |
5 mg | 1507370-20-8 | ¥496.00 | 询底价 |
100 mg | 1507370-20-8 | ¥2,570.00 | 询底价 |
2 mg | 1507370-20-8 | ¥297.00 | 询底价 |
25 mg | 1507370-20-8 | ¥1,290.00 | 询底价 |
Product Introduction
Bioactivity
英文名: BC-1215
描述: BC-1215 是一种 F-box protein 3 抑制剂。它能够稳定 TRAF1-TRAF6 来抑制 Fbxo3-TRAF 激活途径。它与 ApaG 相互作用,阻碍来自人 PBMC 广谱 TH1 细胞因子的分泌。
动物实验: Tested effects of administration of BC-1215 in a model of a cecal ligation and puncture (CLP)-induced sepsis. Mice with CLP had significantly increased cytokine release compared to sham treated mice. BC-1215 treatment significantly attenuated CLP-induced secretion of all three circulating pro-inflammatory cytokines in mice . BC-1215 also decreased bacterial counts in the CLP model and modestly produced inhibition of bacterial growth using Kirby Bauer testing
体内活性: A small molecule inhibitor BC-1215 argeting Fbxo3 was sufficient to lessen severity of cytokine-driven inflammation in several murine disease models.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 3.94 mg/mL (10 mM)
关键字: Ligands for E3 Ligase | E3 ligase-recruiting Moiety | F-box protein 3 (Fbxo3) | Inhibitor | inhibit | inflammation | MLE cells | BC1215 | PBMC cells | U937 cells | BC-1215 | TRAF | BC 1215
相关产品: VL285 | (S,R,S)-AHPC-Me hydrochloride | Thalidomide-5-OH | BSJ-4-116 | (S,R,S)-AHPC-PEG3-N3 | (S,R,S)-AHPC-C10-NH2 | E3 ligase Ligand 8 | Thalidomide-propargyl | (S,R,S)-AHPC-C10-NH2 dihydrochloride | DT2216
相关库: Anti-COVID-19 Compound Library | HIF-1 Signaling Pathway Compound Library | Bioactive Compounds Library Max | Ubiquitination Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途