化合物5-Benzylidene-3-ethyl rhodanine T5822

Product Introduction
Bioactivity


英文名: BTR-1

描述: BTR-1 (5-Benzylidene-3-ethyl rhodanine) 是一种活性抗癌剂， 可激活细胞凋亡并诱导细胞死亡。它能够诱导细胞周期 S 期停滞，影响 DNA 复制。

体外活性: 5-isopropylidiene derivatives of 3-dimethyl-2-thio-hydantoin (ITH-1), 3-ethyl-2-thio-2,4-oxazolidinedione (ITO-1), and 5-Benzylidene-3-ethyl rhodanine(BTR-1), and have tested their chemotherapeutic properties. All three compounds induced cytotoxicity in a time- and concentration-dependent manner on leukemic cell line, CEM. Among the compounds tested, BTR-1 was 5- to 7-fold more potent than ITH-1 and ITO-1 when compared by trypan blue and MTT assays. IC(50) value of BTR-1 was estimated to be <10μM. Both cell cycle analysis and tritiated thymidine assays revealed that BTR-1 affects DNA replication by inducing a block at S phase. BTR-1 treatment led to increased level of ROS production and DNA strand breaks suggesting activation of apoptosis for induction of cell death.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (100.26 mM)


关键字: Inhibitor | inhibit | Apoptosis | BTR1 | BTR-1 | BTR 1

相关产品: Abacavir | Epimedokoreanin B | Nebivolol hydrochloride | (-)-Alkannin | Cirsilineol | PHYTOSPHINGOSINE | Tauroursodeoxycholate | MAZ51 | CPTH2 | EAD1 TFA(1644388-26-0 Free base)

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Apoptosis Compound Library | Covalent Inhibitor Library | Bioactive Compound Library

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