化合物ORY-1001(trans) T5825

Product Introduction
Bioactivity


英文名: Iadademstat dihydrochloride

描述: Iadademstat dihydrochloride (ORY-1001(trans)) 是一种不可逆的选择性赖氨酸特异性脱甲基酶 1A(KDM1A/LSD1) 抑制剂，用于治疗急性白血病。

体外活性: ORY-1001 is a highly potent and selective KDM1A inhibitor that induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic stem cell capacity in AML.

体内活性: ORY-1001 exhibits potent synergy with standard-of-care drugs and selective epigenetic inhibitors, reduces growth of an AML xenograft model, and extends survival in a mouse PDX (patient-derived xenograft) model of T cell acute leukemia.?Surrogate pharmacodynamic biomarkers developed based on expression changes in leukemia cell lines were translated to samples from patients treated with ORY-1001.?ORY-1001 is a selective KDM1A inhibitor in clinical trials and is currently being evaluated in patients with leukemia and solid tumors.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.03 mg/mL (10 mM)


关键字: RO 7051790 | RG 6016 | Iadademstat dihydrochloride | Histone Demethylase | RO7051790 | inhibit | RG6016 | Inhibitor | ORY1001 | RO-7051790 | ORY 1001 | Iadademstat Dihydrochloride | ORY-1001 | Iadademstat | RG-6016

相关产品: LSD1-IN-5 | Procaine | Procaine hydrochloride | T-3775440 hydrochloride | LSD1-IN-30 | GSK 690 Hydrochloride | GSK2879552 | Corin | ML324 | Vafidemstat

相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | Stem Cell Differentiation Compound Library | Preclinical Compound Library | Histone Modification Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途